PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G04340.1
Common NameC2H2, CZF2, T19N18.70, ZAT6
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family C2H2
Protein Properties Length: 238aa    MW: 25252.3 Da    PI: 8.152
Description zinc finger of Arabidopsis thaliana 6
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G04340.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H214.10.0001389111123
                  EEETTTTEEESSHHHHHHHHHHT CS
      zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                  ykC+ C+k Fs+   L  H  +H
  AT5G04340.1  89 YKCSVCDKAFSSYQALGGHKASH 111
                  9***********99999998887 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576675.87E-1088111No hitNo description
SMARTSM003550.007389111IPR015880Zinc finger, C2H2-like
PfamPF139121.8E-1389113IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.602.2E-489111IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015710.26389111IPR007087Zinc finger, C2H2
PROSITE patternPS00028091111IPR007087Zinc finger, C2H2
SuperFamilySSF576675.87E-10143170No hitNo description
SMARTSM003550.35148170IPR015880Zinc finger, C2H2-like
PfamPF139121.3E-11148172IPR007087Zinc finger, C2H2
PROSITE profilePS5015710.014148175IPR007087Zinc finger, C2H2
PROSITE patternPS000280150170IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010200Biological Processresponse to chitin
GO:0055062Biological Processphosphate ion homeostasis
GO:2000280Biological Processregulation of root development
GO:0005634Cellular Componentnucleus
GO:0001047Molecular Functioncore promoter binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008270Molecular Functionzinc ion binding
GO:0043565Molecular Functionsequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0009005anatomyroot
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 238 aa     Download sequence    Send to blast
MALETLTSPR LSSPMPTLFQ DSALGFHGSK GKRSKRSRSE FDRQSLTEDE YIALCLMLLA  60
RDGDRNRDLD LPSSSSSPPL LPPLPTPIYK CSVCDKAFSS YQALGGHKAS HRKSFSLTQS  120
AGGDELSTSS AITTSGISGG GGGSVKSHVC SICHKSFATG QALGGHKRCH YEGKNGGGVS  180
SSVSNSEDVG STSHVSSGHR GFDLNIPPIP EFSMVNGDEE VMSPMPAKKL RFDFPEKP
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.650290.0leaf| root| seed
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306804730.0
Genevisible245711_at0.0
Expression AtlasAT5G04340-
AtGenExpressAT5G04340-
ATTED-IIAT5G04340-
Functional Description ? help Back to Top
Source Description
TAIRputative c2h2 zinc finger transcription factor mRNA,
UniProtProbable transcription factor that regulates root development and phosphate (Pi) acquisition and homeostasis. Probably acts as a repressor of primary root growth and regulates Pi homeostasis through the control of root architecture. {ECO:0000269|PubMed:17631527}.
Function -- GeneRIF ? help Back to Top
  1. AtSWP1 and AtCZS (a C2H2 zinc finger-SET domain protein) represent two main components of a co-repressor complex that fine tunes flowering and is unique to plants.
    [PMID: 17224141]
  2. repressor of primary root growth and regulates phosphate homeostasis through the control of root architecture
    [PMID: 17631527]
  3. these results suggest that phosphorylation by MPK6 is required for the functional role of ZAT6 in seed germination under salt and osmotic stress.
    [PMID: 23257164]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00622PBM24477691Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G04340.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By cold treatment and during Pi starvation. {ECO:0000269|PubMed:15634197, ECO:0000269|PubMed:17631527}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G04340
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF0226580.0AF022658.1 Arabidopsis thaliana putative c2h2 zinc finger transcription factor mRNA, complete cds.
GenBankCP0026880.0CP002688.1 Arabidopsis thaliana chromosome 5 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_196054.11e-173zinc finger protein ZAT6
SwissprotO225331e-175ZAT6_ARATH; Zinc finger protein ZAT6
TrEMBLD7LXH71e-126D7LXH7_ARALL; Putative uncharacterized protein
STRINGAT5G04340.11e-173(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM12112898
Representative plantOGRP13115149
Publications ? help Back to Top
  1. Chrispeels HE,Oettinger H,Janvier N,Tague BW
    AtZFP1, encoding Arabidopsis thaliana C2H2 zinc-finger protein 1, is expressed downstream of photomorphogenic activation.
    Plant Mol. Biol., 2000. 42(2): p. 279-90
    [PMID:10794528]
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  3. Kim JC, et al.
    A novel cold-inducible zinc finger protein from soybean, SCOF-1, enhances cold tolerance in transgenic plants.
    Plant J., 2001. 25(3): p. 247-59
    [PMID:11208017]
  4. Seki M, et al.
    Functional annotation of a full-length Arabidopsis cDNA collection.
    Science, 2002. 296(5565): p. 141-5
    [PMID:11910074]
  5. Vogel JT,Zarka DG,Van Buskirk HA,Fowler SG,Thomashow MF
    Roles of the CBF2 and ZAT12 transcription factors in configuring the low temperature transcriptome of Arabidopsis.
    Plant J., 2005. 41(2): p. 195-211
    [PMID:15634197]
  6. Li P, et al.
    Effects of chronic ozone exposure on gene expression in Arabidopsis thaliana ecotypes and in Thellungiella halophila.
    Plant Cell Environ., 2006. 29(5): p. 854-68
    [PMID:17087469]
  7. Krichevsky A, et al.
    C2H2 zinc finger-SET histone methyltransferase is a plant-specific chromatin modifier.
    Dev. Biol., 2007. 303(1): p. 259-69
    [PMID:17224141]
  8. Gan Y,Liu C,Yu H,Broun P
    Integration of cytokinin and gibberellin signalling by Arabidopsis transcription factors GIS, ZFP8 and GIS2 in the regulation of epidermal cell fate.
    Development, 2007. 134(11): p. 2073-81
    [PMID:17507408]
  9. Zhang J,Cao ML,Huang YB,Wu BJ
    [Study of hrpN(CSDS001) and the gene expression profile of Arabidopsis thaliana induced by Harpin(CSDS001)].
    Yi Chuan, 2007. 29(5): p. 629-36
    [PMID:17548335]
  10. Crawford BC,Ditta G,Yanofsky MF
    The NTT gene is required for transmitting-tract development in carpels of Arabidopsis thaliana.
    Curr. Biol., 2007. 17(13): p. 1101-8
    [PMID:17600712]
  11. Devaiah BN,Nagarajan VK,Raghothama KG
    Phosphate homeostasis and root development in Arabidopsis are synchronized by the zinc finger transcription factor ZAT6.
    Plant Physiol., 2007. 145(1): p. 147-59
    [PMID:17631527]
  12. Ciftci-Yilmaz S,Mittler R
    The zinc finger network of plants.
    Cell. Mol. Life Sci., 2008. 65(7-8): p. 1150-60
    [PMID:18193167]
  13. Pauwels L, et al.
    Mapping methyl jasmonate-mediated transcriptional reprogramming of metabolism and cell cycle progression in cultured Arabidopsis cells.
    Proc. Natl. Acad. Sci. U.S.A., 2008. 105(4): p. 1380-5
    [PMID:18216250]
  14. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  15. Vald
    Transcriptional regulation and signaling in phosphorus starvation: what about legumes?
    J Integr Plant Biol, 2008. 50(10): p. 1213-22
    [PMID:19017108]
  16. Kagale S,Links MG,Rozwadowski K
    Genome-wide analysis of ethylene-responsive element binding factor-associated amphiphilic repression motif-containing transcriptional regulators in Arabidopsis.
    Plant Physiol., 2010. 152(3): p. 1109-34
    [PMID:20097792]
  17. Kodaira KS, et al.
    Arabidopsis Cys2/His2 zinc-finger proteins AZF1 and AZF2 negatively regulate abscisic acid-repressive and auxin-inducible genes under abiotic stress conditions.
    Plant Physiol., 2011. 157(2): p. 742-56
    [PMID:21852415]
  18. Gaudinier A, et al.
    Enhanced Y1H assays for Arabidopsis.
    Nat. Methods, 2011. 8(12): p. 1053-5
    [PMID:22037706]
  19. Causier B,Ashworth M,Guo W,Davies B
    The TOPLESS interactome: a framework for gene repression in Arabidopsis.
    Plant Physiol., 2012. 158(1): p. 423-38
    [PMID:22065421]
  20. Liu XM, et al.
    Phosphorylation of the zinc finger transcriptional regulator ZAT6 by MPK6 regulates Arabidopsis seed germination under salt and osmotic stress.
    Biochem. Biophys. Res. Commun., 2013. 430(3): p. 1054-9
    [PMID:23257164]
  21. Chen J, et al.
    Zinc-Finger Transcription Factor ZAT6 Positively Regulates Cadmium Tolerance through the Glutathione-Dependent Pathway in Arabidopsis.
    Plant Physiol., 2016. 171(1): p. 707-19
    [PMID:26983992]
  22. Tague BW,Goodman HM
    Characterization of a family of Arabidopsis zinc finger protein cDNAs.
    Plant Mol. Biol., 1995. 28(2): p. 267-79
    [PMID:7599312]
  23. Tague BW,Gallant P,Goodman HM
    Expression analysis of an Arabidopsis C2H2 zinc finger protein gene.
    Plant Mol. Biol., 1996. 32(5): p. 785-96
    [PMID:8980531]
  24. Meissner R,Michael AJ
    Isolation and characterisation of a diverse family of Arabidopsis two and three-fingered C2H2 zinc finger protein genes and cDNAs.
    Plant Mol. Biol., 1997. 33(4): p. 615-24
    [PMID:9132053]
  25. Luo M, et al.
    Genes controlling fertilization-independent seed development in Arabidopsis thaliana.
    Proc. Natl. Acad. Sci. U.S.A., 1999. 96(1): p. 296-301
    [PMID:9874812]